Dr Elis Haan talks to Dr Rob Calder about ADHD and maternal substance use. Elis discusses her recent paper exploring the impact of alcohol, caffeine and tobacco during pregnancy on ADHD outcomes in young people.

Elis talks about the differences between maternal and teacher ratings of ADHD. She also explains negative control and polygenic risk score methods used in this study discussing how multiple methods were used across different longitudinal datasets to add confidence to their analysis.

“Combining these different methods can help to gain stronger support for a causal effect…. For example, if these different methods and analyses across these cohorts provide similar results we can be more confident that the results reflect a true causal effect. This is because it is unlikely that these different methods will be all biased in the same way”

Original research: Prenatal smoking, alcohol and caffeine exposure and maternal-reported attention deficit hyperactivity disorder symptoms in childhood: triangulation of evidence using negative control and polygenic risk score analyses. by Elis Haan and colleagues Published in Addiction (2021).

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