This presentation will describe the ongoing role of the National Centre for Health and Clinical Excellence (NICE) in assessing the current evidence relating to the prevention of alcohol use disorders in England. This work deals with adults and young people, aged ten or more, and so is pertinent to the young people and families’ agenda. The recommendations being developed will incorporate both primary and secondary prevention which take the form of upstream (population level) and downstream (practitioner level) interventions. The presentation will also outline the broader ‘alcohol agenda’ being addressed by NICE, which has two further groups that are developing recommendations related to the physical and mental health management of alcohol problems. The opportunities that arise from having national guidance on alcohol, and some of the challenges that arise from dealing with alcohol-related problems in a piecemeal fashion, will be discussed.